This is from 2007, too old for this debate.
The better version is out now.
Too wonky a source cited here.
This is just another one of the scare tactics from those who do not believe our God is sovereign.
It's not a Chinese document so it must be the wrong virus.
Your truth is always legitimate while "my" truth gets to be edited.
https://patentimages.storage.googleapis.com/6b/c3/21/a62eb55a0e678c/US7220852.pdf
(12) United States Patent
Rota et al.
US007220852B1
US 7,220,852 B1
May 22, 2007
(10) Patent No.:
(45) Date of Patent:
(54) CORONAVIRUS ISOLATED FROM HUMANS
(75) Inventors: Paul A. Rota, Decatur, GA (US);
Larry J. Anderson, Atlanta, GA (US);
William J. Bellini, Lilburn, GA (US);
Cara Carthel Burns, Avondale Estates,
GA (US); Raymond Campagnoli,
Decatur, GA (US); Qi Chen, Marietta,
GA (US); James A. Comer, Decatur,
GA (US); Shannon L. Emery, Lusaka
(ZM); Dean D. Erdman, Decatur, GA
(US); Cynthia S. Goldsmith, Lilburn,
GA (US); Charles D. Humphrey, Lilburn, GA (US); Joseph P. Icenogle,
Atlanta, GA (US); Thomas G. Ksiazek,
Lilburn, GA (US); Stephan S. Monroe,
Decatur, GA (US); William Allan Nix,
Bethlehem, GA (US); M. Steven
Oberste, Lilburn, GA (US); Teresa C.
T. Peret, Atlanta, GA (US); Pierre E.
Rollin, Lilburn, GA (US); Mark A.
Pallansch, Lilburn, GA (US); Anthony
Sanchez, Lilburn, GA (US); Suxiang
Tong, Alpharetta, GA (US); Sherif R.
Zaki, Atlanta, GA (US)
(73) Assignee: The United States of America as
represented by the Secretary of the
Department of Health and Human
Services, Centers for Disease Control
and Prevention, Washington, DC (US)
(*) Notice: Subject to any disclaimer, the term of this
patent is extended or adjusted under 35
U.S.C. 154(b) by 0 days.
(21) Appl. No.: 10/822,904
(22) Filed: Apr. 12, 2004
Related U.S. Application Data
(60) Provisional application No. 60/465,927, filed on Apr.
25, 2003.
(51) Int. Cl.
CI2N 15/50 (2006.01)
CI2N 7/00 (2006.01)
(52) U.S. Cl. ................................. 536/23.72:435/235.1
(58) Field of Classification Search ............. 536/23.72:
514/44; 435/235.1, 320.1
See application file for complete search history.
(56) References Cited
U.S. PATENT DOCUMENTS
2005/0181357 A1* 8, 2005 Peiris et al. ................... 435.5
FOREIGN PATENT DOCUMENTS
WO WO 2004/085.633
WO WO 2004/092360
* 10/2004
* 10/2004
OTHER PUBLICATIONS
GenBank Accession No. AY274119, “SARS Coronavirus Tor2.
complete genome,” version AY274119.1, Apr. 14, 2003.*
GenBank Accession No. AY278487. “SARS coronavirus BJO2,
partial genome,” version AY278487.1, Apr. 21, 2003.*
Genbank Accession No. AY278554, “SARS coronavirus CUHK
W1, complete genome.” version AY278554.1, Apr. 18, 2003.*
GenBank Accession No. AY278491, “SARS Coronavirus HKU
39849, complete genome,” version AY278491.1, Apr. 18, 2003.*
SARS-associated Coronavirus. Genomic Sequence Availability.
online retreived on Aug. 8, 2005). Retreived from the Internet
<URL:
http://www.bcgsc.ca/bioinfo/SARS->.*
GenBank Accession No. AY274119, Apr. 14, 2003.
GenBank Accession No. AY278741, Apr. 21, 2003.
“Update: Outbreak of Severe Acute Respiratory
Syndrome Worldwide, 2003.” MMWR Weekly 52:241-248 (2003).
Emery et al., “Real-Time Reverse Transcription-Polymerase Chain
Reaction Assay for SARS-Associated Coronavirus.” Emerg. Infect.
Diseases 10:311-316 (2004).
Goldsmith et al., “Ultrastructural Characterization of SARS
Coronavirus,” Emerg. Infect. Diseases 10:320-326 (2004).
Ksiazek et al., “A Novel Coronavirus Associated with Severe Acute
Respiratory Syndrome.” N. Eng. J. Med. 348: 1953-1966 (2003).
Luo and Luo, “Initial SARS Coronavirus Genome Sequence Analy sis. Using a Bioinformatics Platform.” 2"Asia-Pacific Bioinformat
ics Conference (APBC2004), Dunedin, New Zealand (2004).
Marra et al., “The Genome Sequence of the SARS-Associated
Coronavirus,” Science 300: 1393-1404 (2003).
Supplementary Online Material for Marra et al. <<www.
sciencemag.org/cgi/content/full/1085953/DC1cd.
Rota et al., “Characterization of a Novel Coronavirus Associated
with Severe Acute Respiratory Syndrome,” Science 300: 1394-1399
(2003).
Supplementary Online Material for Rota et al. <<
www.sciencemag. org/cgi/content/full/1085952/DC1cc.
* cited by examiner
Primary Examiner Mary E. Mosher
(74) Attorney, Agent, or Firm—Klarduist Sparkman LLP
(57) ABSTRACT
Disclosed herein is a newly isolated human coronavirus
(SARS-CoV), the causative agent of severe acute respiratory syndrome (SARS). Also provided are the nucleic acid
sequence of the SARS-CoV genome and the amino acid
sequences of the SARS-CoV open reading frames, as well as
methods of using these molecules to detect a SARS-CoV
and detect infections therewith. Immune stimulatory com
positions are also provided, along with methods of their use.
1 Claim, 7 Drawing Sheets