I would agree with this in large part with the exception of the last part.
I think we see that Antiochus Epiphanes is an immediate fulfillment of the Prophecy and in regards to the horns, the four horns do, I believe, represent the Kingdoms which arise from Alexander's fall, and indicate the leadership, which ties it to Antichrtist's (then Antiochus) rule.
Remember that at this time there was no Roman Empire.
In Revelation we see horns again:
Revelation 17:9-13
King James Version (KJV)
9 And here is the mind which hath wisdom. The seven heads are seven mountains, on which the woman sitteth.
10 And there are seven kings: five are fallen, and one is, and the other is not yet come; and when he cometh, he must continue a short space.
11 And the beast that was, and is not, even he is the eighth, and is of the seven, and goeth into perdition.
12 And the ten horns which thou sawest are ten kings, which have received no kingdom as yet; but receive power as kings one hour with the beast.
13 These have one mind, and shall give their power and strength unto the beast.
Seven Kings (Empires), and at the time five are fallen (Egypt, Babylon, Assyria, Medo-Persia, and Greece), one is (Rome), and the other is not yet come (which excludes Rome and the First Century as having fulfilled this).
That final "King" has but a short space and Antichrist is the little horn which arises from these horns. He arises out of the seven Empires, which has ten horns (i.e. rulers, kings, governors).
The ten horns:
Revelation 17:3-7
King James Version (KJV)
3 So he carried me away in the spirit into the wilderness: and I saw a woman sit upon a scarlet coloured beast, full of names of blasphemy, having seven heads and ten horns.
4 And the woman was arrayed in purple and scarlet colour, and decked with gold and precious stones and pearls, having a golden cup in her hand full of abominations and filthiness of her fornication:
5 And upon her forehead was a name written, Mystery, Babylon The Great, The Mother Of Harlots And Abominations Of The Earth.
6 And I saw the woman drunken with the blood of the saints, and with the blood of the martyrs of Jesus: and when I saw her, I wondered with great admiration.
7 And the angel said unto me, Wherefore didst thou marvel? I will tell thee the mystery of the woman, and of the beast that carrieth her, which hath the seven heads and ten horns.
Satan stands behind the evil empires of history. They have always been in opposition to God and Christ.
The seven "kings" represent the world empires, the last having ten "kings," and Antichrist being of the Seven which indicates a takeover of the last Empire. He will rise up in the midst of this empire and take control, being supported by the ten kings:
12 And the ten horns which thou sawest are ten kings, which have received no kingdom as yet; but receive power as kings one hour with the beast.
13 These have one mind, and shall give their power and strength unto the beast.
I do not see this as speaking of the Pope, lol, but of a politician or ruler within a New World Order or Alliance of nations. The EU is a possible candidate, and if we see the US join ranks with them watch out.
I think we can say that horns are used to represent individual rulers.
God bless.