From Dr Malone today letting you know about the latest expensive ‘offering’ being touted as being used by Biden……who continues to test positive.
SARS-CoV-2 (the cause of COVID-19) is an RNA virus, just like HIV is an RNA virus. RNA viruses evolve very rapid and have a lot of genetic mutations. And just like HIV,
the COVID-19 virusevolves so quickly that it evolves right out from under single “mechanism of action” (single agent) drug therapy. When a patient begins taking Paxvovid, it appears that the drug keeps many of the viruses from reproducing. Because some of the new mutations happen to have a certain level of resistance to the drug, some viruses do survive. Because of COVID-19’s speedy evolution, the virus responds to selection pressures quickly. So, viruses that happen to survive the drug are favored and then resistant virus strains evolve within the patient. When a patient is immunosuppressed and doesn’t clear the virus (as seems to be happening with Paxvovid), then this evolution has a longer runway to evolve before the virus is cleared by the body. These new strains are then spread through out the population. So, other people can contract the escape mutant resistant lineage. A new variant is born.
When HIV single dose therapies failed, physicians soon realized that basic evolutionary theory leads to a solution from this dilemma. That is evolution of resistant viral strains can be delayed by prescribing a multi-drug therapy. That is why so many early, multi-drug treatment docs used drug cocktails.
So why is it,
that the FDA, knowing this - did not chose to exclude immunocompromised individuals from using the drug?
Severely immunocompromised patients can experience prolonged periods of SARS-CoV-2 replication, which may lead to rapid viral evolution. There are theoretical concerns that using a single antiviral agent in these patients may produce antiviral-resistant viruses. Additional studies are needed to assess this risk. The role of combination antiviral therapy or a longer treatment duration in treating severely immunocompromised patients is not yet known.
Right now, patients consuming the Pfizer drug as a single agent therapeutic are increasing the risk of spawning resistant escape mutant variants. If you want a case example of how this works - just look to President Biden and his current treatment plan. That is, round three of the current treatment plan. That is two and a half weeks of having circulating virus in his body. That virus is busy evolving to escape the drug and/or his vaccine.
Now, what we learned also from HIV is that the virus mutates so rapidly, that it evolves so quickly, that it evolves right out from under vaccines - particularly in immunosuppressed patients, who do not rapidly clear the virus. Then vaccine escape mutants are generated with are resistant to the vaccine. So, the fact that Paxlovid is prolonging the virus in the body can only lead to more vaccine escape mutants.
One might think that Pfizer and Moderna wanted to prolong this outbreak…
Naw, that would be too cynical, even for them, right?