You asked for it.
Marijuana not associated with tobacco-associated cancers nor cancers at these sites: colorectal, lung, melanoma, prostate, breast, or cervix. Among men who never smoked cigarettes, having smoked marijuana is associated with a sligh risk of prostate cancer. (Sidney
et al.
Cancer Causes and Control,
1997,
722.)
THC and a variety of analogues show pain-killing effects, varying depending on the modified side-chain and method of administration. (Wiley
et al.
European Journal of Pharmacology,
2000,
319.)
Case study: A man with metastatic cancer and intractible nausea and vomiting received no relief from medication until THC (Marinol) was added. (Gonzales-Rosales and Walsh.
Journal of Pain and Symptom Management,
1997,
311.)
THC increases appetite in rat pups by action at the CB1 receptor in the brain, it is believed the mechanism in people is the same. (Berry and Mechoulam.
Pharmacology and Therapeutics,
2002,
185.)
A variety of marijuana-derived cannabinoids show anti-inflammatory and analgesic effects. (Zourier.
Journal of Cellular Biochemistry,
2003,
462.)
Animal models of multiple schlerosis show cannnabinoid induced reductions in tremor and spasticity mediated by cannabinoid receptors CD1 and CD2. (Pertwee.
Pharmacology and Therapeutics,
2002,
165.)
A randomized double-blind placebo controlled crossover single-dose trial shows that the tics (motor and vocal) and obsessive-compulsive behaviour associated with Tourette's Syndrome are reduced by treatment with THC. (Muller-Vahl
et al.
Pharmacopsychiatry,
2002,
57.)
Opinions:
Medical marijuana should be legalized as no equivalent synthetic drug is available, the benefits of the treatment outweigh the drawbacks (psychotropic side-effects), marijuana is safe in terms of causing no serious long-term health problems, and any possible increase in recreational use spurred by legalization for medical use will be outweighed by the relief of suffering for the critically and terminally ill. (Barnes.
Bioethics,
2000,
16.)
Cannabis and cannabinoids have clear medical uses. Synthetic cannabinoids ineffective in some patients due to the difficulty in titrating the necessary dose and the restriction to an oral route of administration. Useful synthetic analogues are unlikely to be manufactured because the market is too small to make it economical (the "orphan drug" phenomenon). Until an alternative effective route for THC is discovered or synthetic analogues have been made, the best way to care for the needs of the critically or terminally ill is to legalize marijuana for personal medical use at the patient's own risk. (Hall and Degen-hardt.
CNS Drugs,
2003,
689.)
The medical usefulness of marijuana is inconsistent with its classification as a schedule 1 drug (an addictive drug without medical value). Considering that tobacco, alcohol, and commonly-used painkillers are more dangerous than marijuana, the government has inadequate excuse to interfere with the health-care of those patients who might benefit from medical marijuana. (
The Lancet Oncology,
2001, 251.)