How do N95 masks block SARS-CoV-2?
N95 masks are designed to remove more than 95% of all particles that are at least 0.3 microns (µm) in diameter. In fact, measurements of the particle filtration efficiency of N95 masks show that they are capable of filtering ≈99.8% of particles with a diameter of ≈0.1 μm (Rengasamy et al., 2017). SARS-CoV-2 is an enveloped virus ≈0.1 μm in diameter, so N95 masks are capable of filtering most free virions, but they do more than that. How so? Viruses are often transmitted through respiratory droplets produced by coughing and sneezing. Respiratory droplets are usually divided into two size bins, large droplets (>5 μm in diameter) that fall rapidly to the ground and are thus transmitted only over short distances, and small droplets (≤5 μm in diameter). Small droplets can evaporate into 'droplet nuclei', remain suspended in air for significant periods of time and could be inhaled. Some viruses, such as measles, can be transmitted by droplet nuclei (Tellier et al., 2019). Larger droplets are also known to transmit viruses, usually by settling onto surfaces that are touched and transported by hands onto mucosal membranes such as the eyes, nose and mouth (CDC, 2020). The characteristic diameter of large droplets produced by sneezing is ~100 μm (Han et al., 2013), while the diameter of droplet nuclei produced by coughing is on the order of ~1 μm (Yang et al., 2007). At present, it is unclear whether surfaces or air are the dominant mode of SARS-CoV-2 transmission, but N95 masks should provide some protection against both (Jefferson et al., 2009; Leung et al., 2020).
SARS-CoV-2 (COVID-19) by the numbers
N95 masks are designed to remove more than 95% of all particles that are at least 0.3 microns (µm) in diameter. In fact, measurements of the particle filtration efficiency of N95 masks show that they are capable of filtering ≈99.8% of particles with a diameter of ≈0.1 μm (Rengasamy et al., 2017). SARS-CoV-2 is an enveloped virus ≈0.1 μm in diameter, so N95 masks are capable of filtering most free virions, but they do more than that. How so? Viruses are often transmitted through respiratory droplets produced by coughing and sneezing. Respiratory droplets are usually divided into two size bins, large droplets (>5 μm in diameter) that fall rapidly to the ground and are thus transmitted only over short distances, and small droplets (≤5 μm in diameter). Small droplets can evaporate into 'droplet nuclei', remain suspended in air for significant periods of time and could be inhaled. Some viruses, such as measles, can be transmitted by droplet nuclei (Tellier et al., 2019). Larger droplets are also known to transmit viruses, usually by settling onto surfaces that are touched and transported by hands onto mucosal membranes such as the eyes, nose and mouth (CDC, 2020). The characteristic diameter of large droplets produced by sneezing is ~100 μm (Han et al., 2013), while the diameter of droplet nuclei produced by coughing is on the order of ~1 μm (Yang et al., 2007). At present, it is unclear whether surfaces or air are the dominant mode of SARS-CoV-2 transmission, but N95 masks should provide some protection against both (Jefferson et al., 2009; Leung et al., 2020).
SARS-CoV-2 (COVID-19) by the numbers