It's also important to note that this situation is the first biblical example of the younger receiving preference over the older.
Excellent observation [Who Was The Elder Son?]:
Jealousy/envy/enmity from those that were first towards those that were second:
Cain/Abel
4 And Abel, he also brought of the firstlings of his flock and of the fat thereof. And Jehovah had respect unto Abel and to his offering:
5 but unto Cain and to his offering he had not respect. And Cain was very wroth, and his countenance fell.
6 And Jehovah said unto Cain, Why art thou wroth? and why is thy countenance fallen? Gen 4
Ishmael/Isaac
8 And the child grew, and was weaned. And Abraham made a great feast on the day that Isaac was weaned.
9 And Sarah saw the son of Hagar the Egyptian, whom she had borne unto Abraham, mocking. Gen 21
28 Now we, brethren, as Isaac was, are the children of promise.
29 But as then he that was born after the flesh persecuted him that was born after the Spirit, even so it is now. Gal 4
Essau/Jacob
41 And Esau hated Jacob because of the blessing wherewith his father blessed him. And Esau said in his heart, The days of mourning for my father are at hand. Then will I slay my brother Jacob. Gen 27
Saul the first king/David the second king
7 And the women sang one to another as they played, and said, Saul hath slain his thousands, And David his ten thousands.
8 And Saul was very wroth, and this saying displeased him; and he said, They have ascribed unto David ten thousands, and to me they have ascribed but thousands: and what can he have more but the kingdom?
9 And Saul eyed David from that day and forward. 1 Sam 18
Concerning the firstborn/second born, it is consistent throughout the scriptures that it's actually the second born that obtains the favor of God, not the firstborn,
It was not Cain's sacrifice that God had respect for, but it was Abel's; 'Cain was of the evil one, and slew his brother....Because his works were evil, and his brother`s righteous.' [1 Jn 3:12]
Shem was the elder brother of Japheth, but, 'God enlarge Japheth, And let him dwell in the tents of Shem...' [Gen 10:21 ASV & 9:27]
It was Ishmael, the firstborn, that was born after the flesh, and he persecuted Isaac, the second born, that was born after the Spirit. Isaac was the child of promise; Ishmael was cast out. [Gal 4:29]
It was said of Esau and Jacob, 'The elder shall serve the younger. Even as it is written, Jacob I loved, but Esau I hated.' [Ro 9:12,13]
It was not Leah his first wife that Jacob loved, but it was Rachel his second wife. [Gen 29:30,31]
It was Ephraim the younger that Jacob blessed over his older brother Mannassah and that in spite of Joseph's objections. [Gen 48:13-20]
It was not the first generation of the exodus that entered into the rest of the promised land, it was the second generation; 'But your little ones, that ye said should be a prey, them will I bring in, and they shall know the land which ye have rejected.' [Nu 14:31]
It was not Saul the first king of Israel that would do all of God's will, but it was the second king David that was a man after His heart; '...Saul the son of Kish...when he had removed him, he raised up David to be their king; to whom also he bare witness and said, I have found David the son of Jesse, a man after My heart, who shall do all My will.' [Acts 13:21,22]
It was not the first covenant of the law ( I desire mercy, and not sacrifice) that God had pleasure in, but it was the second covenant of grace; '....a better covenant, which hath been enacted upon better promises. For if that first covenant had been faultless, then would no place have been sought for a second.' [Heb 8:6,7]
Consider 'the first man Adam' vs. 'the last Adam, ' ... that is not first which is spiritual, but that which is natural; then that which is spiritual. The first man is of the earth, earthy: the second man is of heaven.' 1 Cor 15:45-47]
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