Here is a sample from MacArthur that will indicate his position on the book and give an excellent example of his commitment to a literal interpretation whenever possible....
"But nowhere in Scripture is there a more detailed description of the coming judgment than in Revelation 6-18. Those chapters describe the future seven-year period known as the Tribulation. Summing up what they reveal about that period, God's judgment will rain down on the earth in the form of the seal, trumpet, and bowl judgments. Although those judgments will be worldwide in scope, they will focus particularly on Antichrist's world empire of Babylon. That empire will involve both a religious and a commercial aspect. At the midpoint of the Tribulation, Antichrist will destroy the false Babylonian religious system, which will be absorbed into commercial Babylon. Religion will not cease to exist, but will be restricted to the worship of Antichrist. The Babylon in view in chapter 18 is Antichrist's worldwide commercial empire, which will rule the world during the last three and a half years of the Tribulation. That Antichrist will be able to build the greatest commercial empire the world has ever known in the midst of the devastating judgments of the Tribulation reveals his incredible power.
God's destruction of commercial Babylon is the theme of chapter 18. It is thus a very somber chapter; it is a requiem, a dirge for the funeral of humanity. With the destruction of the satanic last and greatest human empire, the stage is set for the triumphant return of the Lord Jesus Christ.
Though some commentators view it as a symbol for Antichrist's whole godless system, the Babylon described in chapter 18 is most likely an actual city. It is called a city five times in the chapter (vv 10, 16, 18, 19, 21), and other features in the text imply that a literal city is in view since the text plainly describes Babylon as a city, and there is nothing in the context to indicate otherwise, it is safest to view it as a real city. The specific Old Testament prophecies of Babylon's destruction and perpetual desolation (Isa. 13:19—22; 14:22—23; Jer. 50:13,39; 51:37), as yet unfulfilled, also argue that chapter 18 describes an actual city. But while Babylon will be an actual city its influence will be worldwide. As Antichrist's capital city, it will be the hub of and represent his commercial empire. Thus, the judgment and destruction of Babylon will kill the head, and the rest of the body of Antichrist's whole world empire will follow in death.
Babylon will have received plenty of warnings of its impending doom by the occurrence of the events of chapter 18. The 144,000 Jewish evangelists, the two witnesses, the rest of the redeemed, and an angel flying in the heavens will have proclaimed the gospel message. That message includes the truth that God will judge those who refuse to repent. In addition, earlier in the Tribulation an angel specifically warned of Babylon's impending doom, crying out "Fallen, fallen is Babylon the great, she who has made all the nations drink of the wine of the passion of her immorality" (14:8). The angel spoke of Babylon's yet future fall as if it had already happened, emphasizing the certainty of its doom.
But despite the repeated warnings, the people of the world will refuse to repent (cf. 9:20-21; 16:9,11), and God's judgment will fall on Babylon... "(John MacArthur, Jr., Revelation 12-22, pgs 176-177).