I don't think so. Mary had no other children after Jesus was born. She remained a virgin her entire life. I came to this conclusion in the 7th decade of my life after a careful search of the Scriptures. However, I was unable to reach this conclusion until I opened my mind to the possibility and actually looked at the overwhelming evidence of the perpetual virginity of Mary. Here are some of the things I found.Jesus had sisters too.....so are you gonna say "The Sisters of God"???
1. Scripture never says that Mary had other children. We can only infer this on account of Scriptural references to brothers and sisters of the Lord. However, in the narrative of Jesus being left behind in Jerusalem at age 12, there is no mention of any other children.
2. Reference to brothers and sisters would certainly include the possibility that these people were "half siblings", i.e., children of Joseph. In fact, this belief prevailed in the early church until the time of Jerome (d. 420). Jerome concluded that these brothers and sisters were in fact cousins. In Hebrew and Aramaic there was no word for "cousin" and the relationship was either designated "brother" or it was shown by language such as "son of my father's brother", etc. For example, Genesis 14:14 (KJV) refers to Lot as Abram's brother; in Genesis 29:15 (KJV) Laban calls Jacob his brother; in 2 Kings 10:13-14 (KJV) the 42 captives of Jehu call themselves brothers of Ahaziah. Indeed it is possible that some of the "brothers" of Jesus were half-brothers and others were cousins.
3. When the angel announced the coming birth of the King of Israel, Mary's response was, "How shall this be, seeing I know not a man?" The implication here is that Mary had already committed herself to remain a virgin. The angel did not say when this birth was to take place and Mary was espoused to Joseph at that time. If she had planned on having sexual relations, she would be doing so shortly and it would not be a mystery how the birth was to occur. However, if she planned on remaining a virgin all her life, her question to the angel was perfectly reasonable.
4. None of the early church fathers advocated that Mary had other children. On the other hand, many of them advocated her perpetual virginity. Of particular note among this group were Jerome, Ambrose of Milan (d. 397) and Augustine (d. 430).
5. The early reformers, including Martin Luther, John Calvin and John Wesley advocated the perpetual virginity of Mary.
6. The strongest indicator that Mary had no other children is contained in John 19:26-27, where Jesus places the care of his mother with John. If Mary had other children, this would have been unthinkable at every level imaginable. Not only would it have been highly insulting, it would have been impossible. Jesus would have had no right to do this. In fact, it was when I really thought about this event that I decided Mary did not have any other children.
The only difficult Scripture for those who advocate the perpetual virginity of Mary is Matthew 1:25 ("but [Joseph] kept her a virgin until she gave birth to a Son"). The implication is that Joseph had sexual relations with his wife after the birth of Jesus. But the language of the Bible does not bear this out. For example, consider 1 Corinthians 15:25, "For He must reign until He has put all His enemies under His feet." Should we infer that He ceases to reign after He has put all His enemies under His feet? Likewise, we need not infer that Joseph had sexual relations with his wife after the birth of Jesus.
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